The effect of caffeic acid phenethyl ester (CAPE) on metabolic enzymes including acetylcholinesterase, butyrylcholinesterase, glutathione S-transferase, lactoperoxidase, and carbonic anhydrase isoenzymes I, II, IX, and XII

We report the inhibition effect of Caffeic acid phenethyl ester on four catalytically active isoforms, human carbonic anhydrase I, II, IX, and XII, as well as against AChE, BChE, LPO, and glutathione S-transferases

İlhami Gülçin; Andrea Scozzafava; Claudiu T. Supuran; Hulya Akıncıoğlu; Zeynep Koksal; Fikret Turkan; Saleh Alwasel

2015

Scholarcy highlights

  • Polyphenolic compounds derived from natural products are well known to possess a range of biological activities such as antioxidant, antitumoral, anti-inflammatory, anti-viral, and immunomodulatory properties
  • In order to determine the effect of Caffeic acid phenethyl ester on AChE, different CAPE concentrations were added into the reaction medium
  • CAPE was able to inhibit the gene expression; production and the activity of matrix metalloproteinases induced by lipopolysaccharide and increased the gene expression of human monocytic cell line
  • It modulates the activities of focal adhesion kinase, inducible human immunodeficiency virus integrase, nitric oxide synthase, lipoxygenase, and cyclooxygenase
  • With regard to the anti-inflammatory action of CAPE, it has been reported that CAPE inhibits the enzyme activities of COX
  • It was reported that in Alzheimer’s disease, AChE is lost up to 85% in specific brain regions, whereas BChE levels rise with disease progression
  • The results showed that CAPE moderately inhibited four CA isoenzymes but effectively inhibited the other metabolic enzymes) with diverse inhibition profiles
  • These data may explain the beneficial health effects of some of these compounds and may lead to enzyme researchers and drug design campaigns

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