C-Geranylated flavonoids fromPaulownia tomentosafruits with antimicrobial potential and synergistic activity with antibiotics

The test of the antibacterial activity showed good effects of 30-O-methyldiplacol and mimulone against methicillin-resistant Staphylococcus aureus, and in six cases, the results showed synergistic effects when combined with oxacillin

Alice Navrátilová

2016

Scholarcy highlights

  • Pathogens that have become resistant to antibiotics, represent a critical threat in many hospitals and in communities around the world, and the development of drugs that can combat such infections is urgently needed
  • Bacteria were grown in the Mueller–Hinton broth and Mueller–Hinton agar
  • Potential anti-methicillin-resistant Staphylococcus aureus synergistic effects of compounds 3 and 5 with OXA, TTC, and CIP were measured by the checkerboard titration technique, and the fractional inhibitory concentrations were evaluated according to the guidelines set by the European Committee on Antimicrobial Susceptibility Testing
  • The C-6 geranylated compounds 30-O-methyl-50-hydroxydiplacone, 30-O-methyl-50-O-methyldiplacone, 30-O-methyldiplacol, 30-O-methyldiplacone, mimulone, and diplacone, isolated from P. tomentosa as described previously, were tested for their ability to kill the promastigote forms of four Leishmania species: L. braziliensis, L. donovani, L. infantum and L. panamensis
  • Geranylated flavonoids were effective in lowering the Minimal inhibitory concentrations values of the antibiotics OXA and TTC tested on several MRSA strains
  • The activity of 30-O-methyl substituted dihydroflavonol 3 was diminished probably due to the presence of 3-OH substitution; it is difficult to predict a structure–activity relationship for the compounds tested, because further assay showed that a small structural change of geranylated flavonoid at the ring B can affect the mechanism of antileishmanial effect
  • ARTICLE HISTORY Received 28 May 2015 Accepted 1 October 2015 Revised 5 August 2015 Published online 18 January 2016

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