Recent advances in non-ionic surfactant vesicles (niosomes): self-assembly, fabrication, characterization, drug delivery applications and limitations

This study has revealed minimal ocular irritations indicating good ocular tolerability for niosomes

Hamdy Abdelkader

2013

Scholarcy highlights

  • Manufacturing methods, physical characterization techniques, bilayer membrane additives, unconventional niosomes, their recent applications as drug delivery systems, limitations and directions for future research will be discussed
  • Methotrexate-loaded niosomes were first utilized as a more stable and economic alternative drug delivery system to liposomes, in order to improve the therapeutic index of the anticancer drug by localizing the cytotoxic effects to target cells
  • Ocular toxicity of niosomes has been recently assessed through studying conjunctival and corneal irritation potential of Span 60 niosomes, and Span 60 niosomes containing different concentrations of bilayer membrane additives such as dicetyl phosphate, sodium cholate and Solulan C24 using an acceptable in vitro conjunctival model and excised bovine corneal opacity and permeability models
  • This study has revealed minimal ocular irritations indicating good ocular tolerability for niosomes
  • Liposomes and niosomes are prepared in a sterile form by passing all organic lipid, buffer and drug solutions through bacterial filters; and the final product is prepared under aseptic conditions

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