p38 MAPK: A dual role in hepatocyte proliferation through reactive oxygen species

P38 MAPKs are important mediators of signal transduction that respond to a wide range of extracellular stressors such as UV radiation, osmotic shock, hypoxia, pro-inflammatory cytokines, and oxidative stress

A. M. Tormos; R. Taléns-Visconti; A. R. Nebreda; J. Sastre

2013

Scholarcy highlights

  • P38 MAPKs are important mediators of signal transduction that respond to a wide range of extracellular stressors such as UV radiation, osmotic shock, hypoxia, pro-inflammatory cytokines, and oxidative stress
  • JS's work is supported by grants SAF2009-09500 with FEDER funds
  • ARN's work is supported by the Fundación BBVA
  • It has been reported that reactive oxygen species play a critical role in cytokine-induced p38α activation
  • p38α can function as a mediator of reactive oxygen species signaling

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