Phagocytic Uptake and Cytotoxicity of Solid Lipid Nanoparticles (SLN) Sterically Stabilized with Poloxamine 908 and Poloxamer 407

Solid lipid nanoparticles as alternative intravenous colloidal drug carriers were produced by high pressure homogenisation of melted lipids

R. Müller

2007

Scholarcy highlights

  • Solid lipid nanoparticles as alternative intravenous colloidal drug carriers were produced by high pressure homogenisation of melted lipids
  • Their surface was modified by using hydrophilic poloxamine 908 and poloxamer 407 block-copolymers in order to reduce the phagocytic uptake by the reticuloendothelial system
  • uptake was quantified by chemiluminescence
  • poloxamer 407 reduced the phagocytic uptake to appr
  • 8–15% compared to the phagocytosis of hydrophobic polystyrene particles
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