γ-Rays-generated ROS induce apoptosis via mitochondrial and cell cycle alteration in smooth muscle cells

Purpose: γ-rays cause an increase in intracellular calcium, alters contractility and triggers apoptosis via the activation of protein kinase C in intestinal guinea pig smooth muscle cells

Sandra Claro; Maria Etsuko Miyamoto Oshiro; Renato Arruda Mortara; Edgar Julian Paredes-Gamero; Gustavo José Silva Pereira; Soraya Soubhi Smaili; Alice Teixeira Ferreira

2014

Scholarcy highlights

  • Purpose: γ-rays cause an increase in intracellular calcium, alters contractility and triggers apoptosis via the activation of protein kinase C in intestinal guinea pig smooth muscle cells
  • Apoptosis was mediated by the mitochondria releasing cytochrome c leading to caspase 3 activation
  • IR increased the expression of the cyclins A, B2 and E and led to unbalanced cellular growth in an absorption dose-dependent manner
  • IR increased the nuclear expression of cytoplasmic proteins and cyclins A and E
  • Smooth muscle cells subjected to IR undergo mitochondrial-mediated apoptosis that involves oncoproteins activation and preserves mitochondrial structure
  • IR cause alterations in the expression and localization of both pro- and anti-apoptotic proteins

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