1,25-Dihydroxyvitamin D3Attenuates of Expression of Experimental Murine Lupus of MRL/1 Mice

The murine strain MRL/1 spontaneously develops a systemic lupus erythematosus -like syndrome

Jacques M. Lemire

2008

Scholarcy highlights

  • The murine strain MRL/1 spontaneously develops a systemic lupus erythematosus-like syndrome
  • polyclonal T helper cell activity has been described in these mice suggesting a potential role for 1,25-dihydroxyvitamin-D3
  • the degree of proteinuria was somewhat reduced in treated mice
  • a trend for a reduction in serum titers for anti-ssDNA antibodies was observed at 18 weeks
  • The active vitamin D metabolite had no effect on the development of the generalized lymphoid hyperplasia
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