Recent Trends and Progress in Sustained or Controlled Oral Delivery of Some Water Soluble Drugs: Morphine Salts, Diltiazem and Captopril

This review focuses on the progress made in the design of controlled/sustained release delivery systems for some water soluble drugs

M. I. Zahirul Khan

2007

Scholarcy highlights

  • The development of oral controlled release systems has been a challenge to formulation scientists due to their inability to restrain and localise the system at targeted areas of the gastrointestinal tract
  • A new approach has been the use of mucoadhesive systems to increase the residence time of the device within the GI tract
  • This review focuses on the progress made in the design of controlled/sustained release delivery systems for some water soluble drugs
  • Highly/freely water soluble diltiazem, captopril and morphine salts have been selected as model drugs due to the leading role they play in their respective field of therapy and their widespread use in treating chronic patients
  • Particular emphasis is given to delivery systems designed to achieve their once a day dose treatment
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