Lipid nanoparticles as an emerging platform for cannabinoid delivery: physicochemical optimization and biocompatibility

This work aims at developing and optimizing a valuable oral delivery carrier for the cannabinoid derivative CB13, which presents a high therapeutic potential in chronic pain states that respond poorly to conventional analgesics, and shows highly unfavorable physicochemical properties

M. DurĂ¡n-Lobato

2015

Scholarcy highlights

  • This work aims at developing and optimizing a valuable oral delivery carrier for the cannabinoid derivative CB13, which presents a high therapeutic potential in chronic pain states that respond poorly to conventional analgesics, and shows highly unfavorable physicochemical properties
  • CB13-loaded lipid nanoparticles formulations were developed through solvent-emulsion evaporation
  • An optimized formulation of lipid nanoparticles containing CB13 was obtained from a wide range of conditions assayed
  • The LNP formulation proposed proved to be a promising carrier for the oral delivery of CB13
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