Mitogen-activated protein kinase pathways in redox signaling

It has been known for quite some time that proper cellular function requires tight control of the cellular redox state

Martine Torres

2007

Scholarcy highlights

  • It has been known for quite some time that proper cellular function requires tight control of the cellular redox state
  • In contrast to high levels of reactive oxygen species that may induce modifications that inhibit the activity of cellular components or result in damage, repair and cell death, the hypothesis that low levels of ROS, produced enzymatically and in a regulated fashion, are required participants of signaling pathways controlling essential cellular function is gaining grounds
  • Receptor-ligand interaction leads to activation of a phosphorylation cascade where the minimal module is formed by mitogen-activated protein kinases, MAPK kinase and MAPK kinase kinase
  • This review will summarize recent findings regarding the activation of the MAPK and the role played by ROS in their activation
  • This review will summarize recent findings regarding the activation of the mitogen-activated protein kinases and the role played by reactive oxygen species in their activation

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