Insights into the pathogenesis and pathogenicity of cerebral amyloid angiopathy

Amyloid-beta cerebral amyloid angiopathy affects most Alzheimer's disease patients and ~30% of otherwise-normal elderly people

Seth Love

2009

Scholarcy highlights

  • Amyloid-beta cerebral amyloid angiopathy affects most Alzheimer's disease patients and ~30% of otherwise-normal elderly people
  • CAA develops when Abeta is deposited in the vessel walls along or across which it normally passes into the CSF and bloodstream
  • Vascular deposition is facilitated by factors that increase Abeta40:Abeta, impede perivascular passage of Abeta or raise its concentration
  • The levels of some Abeta-degrading enzymes are reduced in AD patients with CAA
  • CAA is a cause of intracerebral haemorrhage and cerebral ischaemic damage
  • In AD, neuritic degeneration is accentuated around Abeta-laden vessels
  • The balance between parenchymal and cerebrovascular degradation of Abeta, and regulation of perivascular extracellular matrix production, are likely to be key determinants of Abeta distribution and pathogenicity within the brain

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