Pesticides and impairment of mitochondrial function in relation with the parkinsonian syndrome

The Parkinsonian syndrome induced by pesticides is associated with the impairment of mitochondrial function

Carmen Gomez

2006

Scholarcy highlights

  • The Parkinsonian syndrome induced by pesticides is associated with the impairment of mitochondrial function
  • Rotenone and pyridaben markedly decreased mtNOS functional activity with NAD-dependent substrates but not when the substrate was succinate. This observation suggest than mtNOS activity is regulated by the activity of complex I
  • This regulation and the role of mitochondrial NO diffusion as a signal for mitochondrial biogenesis could have a role in the etiopathology of Parkinson's disease

Need more features? Save interactive summary cards to your Scholarcy Library.