Histamine 2 Receptor Agonism and Histamine 4 Receptor Antagonism Ameliorate Inflammation in a Model of Psoriasis

This study reveals that treatment with histamine 2 receptor agonists, and blockade of the histamine 4 receptor ameliorates inflammation in a mouse model of psoriasis and diminishes psoriasis-associated itch

K Rossbach; K Wahle; G Bruer; R Brehm; M Langeheine; K Rode; K Schaper-Gerhardt; R Gutzmer; T Werfel; M Kietzmann; W Bäumer

2020

Scholarcy highlights

  • Psoriasis is a chronic autoimmune disease characterized by a hyperproliferative epidermis consisting of premature keratinocytes, incomplete cornification and an elevated immune cell infiltration
  • Histamine might play a pathogenetic role in psoriasis, since histamine increases the proliferation of keratinocytes, and elevated histamine levels can be found in psoriatic skin
  • This study reveals that treatment with histamine 2 receptor agonists, and blockade of the histamine 4 receptor ameliorates inflammation in a mouse model of psoriasis and diminishes psoriasis-associated itch
  • Topical application of IMQ cream induces an inflammatory response in the skin that mimics psoriasis, with similar immunological pathways and cell types involved
  • Two studies showed that histamine levels in psoriatic skin were higher than those in healthy skin
  • H2R and H4R are expressed on murine dorsal root ganglia and, for H4R at least, it was shown that stimulation of the receptor leads to Ca2+ influx in DRG
  • This study found that combined treatment with an H2R agonist and H4R antagonist ameliorated skin inflammation and pruritus in a mouse model of psoriasis

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