Comparison of EarlyversusLate Use of Antibiotic Locks in the Treatment of Catheter-Related Bacteremia

This study demonstrated that early use of Antibiotic lock solutions along with systemic antibiotics can be more effective in resolving the symptoms and eradicating catheterrelated bacteremias without the need to exchange the catheters in the majority of the cases

Ali Mirza Onder; Jayanthi Chandar; A. A. Billings; Nancy Simon; Rosa Diaz; Denise Francoeur; Carolyn Abitbol; Gaston Zilleruelo

2008

Scholarcy highlights

  • Background and objectivesThis retrospective study compared the effectiveness of the timing of the antibiotic locks to clear catheter-related bacteremia in children on chronic hemodialysis
  • Recurrence of catheter-related bacteremia within 45 d after wire-guided exchange occurred at similar rates compared with the antibiotic lock groups
  • This study demonstrated that early use of Antibiotic lock solutions along with systemic antibiotics can be more effective in resolving the symptoms and eradicating catheterrelated bacteremias without the need to exchange the catheters in the majority of the cases
  • The infection-free survivals of the catheters that were wire-guided exchange for CRB was longer than both ABL groups, but it is interesting that there was no difference between the incidence of recurrence in the first 6 wk between the WGE and the ABL groups
  • Our study suggests that early ABL use can control the symptoms and clear the CRB in the majority of cases
  • Because of its promise to preserve vascular access sites, the importance of catheter in situ treatment cannot be overemphasized in the hemodialysis population
  • The efficacy and the cost-effectiveness of different Antibiotic lock solutions need to be investigated in prospective, randomized, controlled trials

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