Hybrid Matrix Grafts to Favor Tissue Regeneration in Rabbit Femur Bone Lesions

These results show that implants of hybrid matrixes of bioactive glass are capable of promoting bone regeneration

Dante Pascual Goy

2012

Scholarcy highlights

  • Several areas such as orthopedic and oncologic surgery, sports injuries, stomatology, neurosurgery, and maxillofacial surgery, may require the use of implant techniques
  • The present work aimed to: 1) test various polyvinyl alcohol/bioactive glass hybrid materials for in vitro cytotoxicity and select the one presenting the lowest levels of cytotoxicity, and 2) to test the material in an in vivo implant procedure, in an experimental model of New Zealand rabbit femur bone lesions, considering a) whether or not an integration phenomenon has occurred and b) whether or not an inflammatory phenomena of rejection has occurred
  • Aqueous solutions of polyvinyl alcohol were prepared to 28%, dissolving the powder for two hours at 80oC, with continuous shaking
  • The sample which presented the higher cell viability, and the lowest cytotoxic effect, was the material that had been crosslinked with 5% glutaraldehyde solution
  • The model selected for this study was a femoral bone lesion of three-year old female New Zealand rabbits to consider if the positioning of the mentioned implant did promote the regeneration of de novo bone tissue, and whether or not the rejection phenomena could be discarded
  • The developed surgical strategy showed a high level of effectiveness with regard to the parameters of post-surgical monitoring that should be considered when implementing this type of therapeutic strategy, given that the injured rabbits, both those that received the replacement matrixes and those that did not, showed no alterations in water consumption, in day and night temperatures, or in altered patterns in the hemograms
  • A type of hybrid foam was obtained using the sol-gel method, and was later cut in a specific volume and shape, to be used as an implant in a femoral lesion model

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