Oxidative Stress and Psychological Disorders

This review examines some of the recent discoveries that link oxidative status with anxiety, depression, schizophrenia and bipolar disorder

Samina Salim

2014

Scholarcy highlights

  • A widely accepted theory is that chronic, persistent stress triggers numerous illnesses
  • If we focus on stress as an “emotional factor”, the association between stress, anxiety, depression and cognitive dysfunction comes to mind
  • In recent studies from our lab, we observed that the expression of two antioxidant enzymes involved in the oxidative stress pathway and implicated in anxiety-like behaviors, glyoxalase-1 and glutathione reductase-1, were reduced in the hippocampus, amygdala and the cortex of pro-oxidant buthionine-sulfoximine treated rats, which was prevented with antioxidant grape powder treatment
  • Substantial data support the concept that depression is accompanied with heightened oxidative stress and that antidepressant treatments may reduce oxidative stress, suggesting that perhaps augmentation of antioxidant defenses is one of the mechanisms underlying the neuroprotective effects of antidepressants
  • To what extent oxidative stress contributes to specific clinical symptomatology of these complex and debilitating psychiatric ailments remains to be seen
  • A major question remains regarding the causal role of oxidative stress in these illnesses, which is highly critical for early and preventive intervention

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