Exercise-Induced Oxidative Stress

Assays for the most popular markers of exercise-induced oxidative stress may experience methodological flaws, there is sufficient credible evidence to suggest that exercise is accompanied by an increased generation of free radicals, resulting in a measurable degree of oxidative modifications to various molecules

Niels B J Vollaard; Jerry P Shearman; Chris E Cooper

2006

Scholarcy highlights

  • Assays for the most popular markers of exercise-induced oxidative stress may experience methodological flaws, there is sufficient credible evidence to suggest that exercise is accompanied by an increased generation of free radicals, resulting in a measurable degree of oxidative modifications to various molecules
  • It has been demonstrated that reactive oxygen species have the capacity to contribute to the development of muscle fatigue in situ, but there is still a lack of convincing direct evidence that ROS impair exercise performance in vivo in humans
  • It remains unclear whether exercise-induced oxidative modifications have little significance, induce harmful oxidative damage, or are an integral part of redox regulation
  • It is clear that ROS play important roles in numerous physiological processes at rest; the detailed physiological functions of ROS in exercise remain to be elucidated

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