Fracture risk in patients with type 2 diabetes mellitus and possible risk factors: a systematic review and meta-analysis

The result of our meta-analysis showed increased risk of overall fractures in diabetic men compared with diabetic women

Ardeshir Moayeri

2017

Scholarcy highlights

  • Diabetes is an increasingly prevalent disease, with significant associated morbidity and mortality. Type 2 diabetes mellitus is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. Long-term hyperglycemia and inadequate glycemic control both contribute to the development of diabetic complications, including nephropathy, retinopathy, neuropathy, and macrovascular diseases such as acute coronary syndrome, claudicatio intermittens, and stroke.1–3Besides micro- or macrovascular long-term complications, T2DM patients have various skeletal disorders, including osteoporosis and fractures. Diabetes could impact the bone through several mechanisms, some of which may have contradictory effects. The bone turnover and, the skeletal integrity may be affected by diabetes, and diabetic bone disease can represent an overlooked complication of diabetes. Diabetic osteopathy is characterized by microarchitectural changes that decrease the bone quality and strength, leading to an increased risk of bone fracture submit your manuscript | www.dovepress.com Dovepress http://dx.doi.org/10.2147/TCRM.S131945
  • In our effort to identify the variables contributing to the higher risk of fracture among diabetic patients, we found a range of risk factors for fracture that are associated with diabetes
  • Our findings showed a positive association between T2DM and hip fractures, vertebral fractures, submit your manuscript | www.dovepress.com Dovepress
  • We found no association between T2DM and wrist fractures, proximal humerus fractures, or ankle fractures
  • We found no significant association between T2DM and fracture incidence by smoking status
  • The results of this meta-analysis strongly support an association between T2DM and increased risk of any fracture
  • With a worldwide increasing prevalence of diabetes, the contribution of diabetes to the incidence of low-trauma fracture may increase

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