The ability of streptomycin-loaded chitosan-coated magnetic nanocomposites to possess antimicrobial and antituberculosis activities

This study introduces for the first time a new type of magnetic nanoparticle with microorganism theranostic properties as a potential tool to both diagnose and treat diverse microbial and tuberculosis infections

Mohamed El Zowalaty


Scholarcy highlights

  • Nanomaterials are compounds of interest in numerous fields, including physics and chemistry, because the reduced dimension of a solid material leads to novel, unexpected physical and chemical properties that differ from that of the corresponding bulk material. The foundation of these unexpected properties is due to the large surface-to-volume ratio of these nanoparticles, compared to their micron equivalents. Iron oxide nanoparticles are an example of an ultra-small nanomaterial, which are beginning to revolutionize science. In addition, iron oxide nanoparticles are promising candidates for drug delivery, contrast enhancers in magnetic resonance imaging medical diagnostics, and are promising antimicrobial agents to combat bacteria resistant to conventional antibiotics.6Infections caused by antibiotic resistant microorganisms are increasing globally, reaching epidemic proportions. Antimicrobial resistance to various classes of antibiotics is on the rise, with the emergence of multiple drug resistance among different microorganisms raising great concern in clinical settings. The escalating rate of microbial resistance to several different classes of antimicrobial agents raises significant global
  • The efficiency of the nanoparticles in inhibiting the growth of microorganisms was determined by differences in the equivalent number of colony-forming unit before and after treatment as the percentage of microbes that were inhibited by the particles, and inhibition rate was calculated by using Equation 1
  • This study introduces for the first time a new type of magnetic nanoparticles with microorganism theranostic properties as a potential tool submit your manuscript | Dovepress
  • MNPs were synthesized by the coprecipitation of Fe2+ and Fe3+ iron salts in alkali media
  • MNPs were coated by CS to produce CS-MNPs
  • Ferric chloride with 99% purity and ferrous chloride were obtained from Merck KGaA, sodium hydroxide, and Strep sulfate were obtained from Sigma-Aldrich
  • Strep was loaded onto the surface of CS-MNPs to form a Strep-CSMNP nanocomposite
  • Since these nanoparticle bacteria fighters are magnetic, one can envision magnetic field direction of these nanoparticles to fight unwanted microorganism presence on demand

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