Development and evaluation of pH-responsive single-walled carbon nanotube-doxorubicin complexes in cancer cells

This study suggests that while SWNTs have great potential as a drug carrier, the efficient formulation strategy requires further study

Jinping Cheng; Gu; Jin; Shuk Han Cheng; Wong

2011

Scholarcy highlights

  • Most of the existing anticancer drugs are very potent small molecules, their efficacy is constrained by their side effects and as a result of drug resistance and limited cellular entry
  • SWNTs themselves at the concentrations used for SWNT-Hydrazinobenzoic acid-DOX and SWNT-DOX formulations did not affect the survival of HepG2 cells after exposure to PEGylated SWNTs for up to 72 hours, which is similar to previous reports
  • A highly effective drug-delivery system based on SWNTs coated with DOX through hydrazone bond was developed, which improved the loading and release efficiency of DOX
  • The cellular uptake of DOX can be enhanced by employing a hydrazone linkage between DOX molecules and SWNTs
  • With enhanced intracellular accumulation of the drugs, SWNT-HBA-DOX conjugate demonstrated significantly improved cytotoxicity as compared with SWNT-DOX formed through supramolecular interaction
  • These results suggest that the hydrazone bond appears to be beneficial in developing more efficient drug release from SWNT
  • The cellular uptake of DOX can be enhanced by employing a hydrazone linkage between DOX molecules and SWNTs. with enhanced intracellular accumulation of the drugs, SWNT-Hydrazinobenzoic acid-DOX conjugate demonstrated significantly improved cytotoxicity as compared with SWNT-DOX formed through supramolecular interaction

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