In vitro and in vivo evaluation of a sublingual fentanyl wafer formulation

These results indicate that this wafer has potential as an alternative sublingual fentanyl formulation

Stephen Lim

2013

Scholarcy highlights

  • Fentanyl is an opioid analgesic suitable for adult and pediatric patients
  • The median absolute ¬≠bioavailability was 53.0%. These results indicate that this wafer has potential as an alternative sublingual fentanyl formulation
  • This study describes the development and evaluation of the physicochemical properties of a sublingual fentanyl wafer, including a pilot investigation of its bioavailability and pharmacokinetic profile in surgical patients
  • Stability studies showed that the fentanyl wafers remained stable for more than 2 years when stored at room temperature in a desiccator
  • The fentanyl wafer studied was a solid dispersion of amorphized fentanyl in a porous matrix
  • Advice to rinse the mouth with water prior to insertion may be advisable using other sublingual products for which a rapid onset of action is desired

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