Differential Effects of Various Soy Isoflavone Extracts on Bacterial Growth and Human Fibroblast Viability

These results indicate that effects of various soy isoflavone extracts on bacterial growth and viability of human cells are different, despite similar declared composition of the commercially available products

Agata Rzeszótko; Aleksandra Blendowska; Grzegorz Węgrzyn; Karolina Pierzynowska


Scholarcy highlights

  • Flavonoids are polyphenolic compounds present in many food products, including vegetables, fruits, tea and others
  • Our results indicated differential effects of various soy isoflavone extracts on bacterial growth and human fibroblast viability, highlighting the problem of different quality of certain dietary supplements and nutraceuticals sold over-the-counter in vast majority of, if not all, countries
  • Genistein impaired growth of V. harveyi in both time periods, while it had no significant effect on E. coli
  • Differential effects were observed for various soy isoflavone extracts
  • Extract 4 revealed the weakest effect on V. harveyi growth, as the only considerable change in growth rate was noted only at the highest tested concentration between 60 and 120 min after culture supplementation
  • Considerable contaminations were detected in isoflavone-poor extracts. These facts should be taken into account when the use of soy isoflavone extracts is considered, especially as local concentrations of the compounds included in a tablet can be high in human intestine after oral administration of these nutraceuticals or dietary supplements

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