Hypothyroidism alters the expression of Bcl-2 family genes to induce enhanced apoptosis in the developing cerebellum

We evaluated the effect of hypothyroidism on Bcl-2 family gene expression in the developing rat cerebellum

R Singh; G Upadhyay; S Kumar; A Kapoor; A Kumar; M Tiwari; MM Godbole

2004

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  • Bcl-2 family gene expression is known to determine the fate of cells to undergo apoptosis
  • We evaluated the effect of hypothyroidism on Bcl-2 family gene expression in the developing rat cerebellum
  • Extensive DNA fragmentation and enhanced cleavage of DFF-45 were seen throughout development and adulthood whereas they were absent in the euthyroid state
  • The anti-apoptotic genes Bcl-2 and Bcl-xL were down-regulated and the pro-apoptotic gene Bax was expressed at higher levels compared with the euthyroid state
  • These results suggest that normal levels of Thyroid hormone prevent cerebellar apoptosis to a large extent, whereas hypothyroidism increases the extent and the duration of apoptosis by down-regulating the anti-apoptotic genes and maintaining a high level of the pro-apoptotic gene Bax

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