Changes in cytosolic 3,5,3′-tri-iodo-l-thyronine (T3) binding activity during administration of l-thyroxine to thyroidectomized rats: cytosolic T3-binding protein and its activator act as intracellular regulators for nuclear T3 binding

These results suggest that thyroid hormone increases the capacity for cytosolic T3 binding through increasing the amount of CTBP and its activator, and that these increases play a role in regulating the amount of T3 that binds to its nuclear receptor

Y. Nishii; K. Hashizume; K. Ichikawa; T. Miyamoto; S. Suzuki; T. Takeda; K. Yamauchi; M. Kobayashi; T. Yamada

2008

Scholarcy highlights

  • Changes in the amount of cytosolic 3,5,3′-tri-iodo-l-thyronine-binding protein and its activator during administration of l-thyroxine to thyroidectomized rats were investigated
  • Thyroidectomy decreased the amount of CTBP in the kidney, whereas the activator was not significantly modified by thyroidectomy
  • A T4-induced increase in maximal binding capacity in cytosol inhibited nuclear T3 binding in vitro by competition of T3 binding between CTBP and the nuclear receptor
  • These results suggest that thyroid hormone increases the capacity for cytosolic T3 binding through increasing the amount of CTBP and its activator, and that these increases play a role in regulating the amount of T3 that binds to its nuclear receptor

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