MODELING/GIS, RISK ASSESSMENT, ECONOMIC IMPACT

N,N-diethyl-3-methylbenzamide is the most effective and best-studied arthropod repellent currently on the market

Novel Carboxamides as Potential Mosquito Repellents

2010

Scholarcy highlights

  • N,N-diethyl-3-methylbenzamide is the most effective and best-studied arthropod repellent currently on the market
  • The candidates were tested for both duration of repellency and the minimum effective dosage
  • The modeling of the carboxamide data set did not produce a predictive model with a clear physicochemical interpretation correlating compound structure and repellent efÞcacy against Ae. aegypti, there were still some promising leads from this study
  • Many of these predicted and synthesized compounds were repellent in some capacity, with four carboxamides exceeding the repellent duration of deet when tested on cloth at the 25 ␮mol/cm2 dosage
  • Duration of repellency measured by protection time is often used when evaluating repellents, the MED of a repellent needed to prevent arthropod bites minimizes the inßuence of evaporative loss of repellent and provides an indication of the relative potency level of a repellent
  • Whereas the predicted carboxamides were not chosen based on MED, the MED of 1-(1-azepanyl)-1-hexanone was similar to that of deet
  • We will examine the Þve best repellents

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