The Role of Peroxiredoxin Family in Cancer Signaling

This review summarizes Prx isoforms and their basic functions, the relationship between the expression level and the physiological role of Prxs in cancer cells, and their roles in regulating cancer-associated signaling pathways.

Yosup Kim; Ho Hee Jang

2019

Scholarcy highlights

  • Cancer is a heterogeneous disease caused by multiple and complex risk factors, and it poses a substantial threat to the quality of human life
  • Peroxiredoxins represent one of the diverse enzymatic antioxidant systems that are distributed across various organelles, and different subtypes of Prxs are stratified according to the number and the position of Cys residues
  • Prx6 facilitates tumorigenesis in lung cancer through its peroxidase activity. Prxs exert their key function of regulation of redox homeostasis through their antioxidant enzymatic activity, which removes intracellular H2O2
  • The 6 Prx isoforms act as H2O2 scavengers in different intracellular compartments
  • A growing number of studies have found that Prxs regulate their expression and activity, acting as oncogenes that promote carcinogenesis in various cancer types
  • As Prxs have been shown to suppress tumorigenesis, more studies are required to verify the potential of Prxs as therapeutic targets in each cancer type

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