In-vitro and In-vivo Evaluation of Niosomal Gel Containing Aceclofenac for Sustained Drug Delivery

These results show that aceclofenac niosomal gels are more effective in reducing the edema than aceclofenac non-niosomal gels, the anti-inflammatory effect of niosomal gels was sustained for longer time

Dina Fathalla

2015

Scholarcy highlights

  • Niosomes are non-ionic stable vesicular system, which can accommodate both hydrophobic and hydrophilic drugs
  • The present study was aimed to develop aceclofenac niosomal gel followed by evaluating different parameters such as, encapsulation efficiency, shape, particle size distribution, in-vitro drug release and skin permeation
  • In-vitro skin permeation study The effect of surfactant type used in the preparation of aceclofenac loaded niosomes can be tested in this study as aceclofenac was delivered from Hydroxyl propyl methylcellulose niosomal gel
  • As compared with the control group treated with placebo, both formulations were highly effective, with a significant difference between them. These results show that aceclofenac niosomal gels are more effective in reducing the edema than aceclofenac non-niosomal gels, the anti-inflammatory effect of niosomal gels was sustained for longer time
  • The results of the present study demonstrated that HPMC niosomal gel formulation containing span 20: cholesterol possesses great potential for prolonging release, enhancing skin permeation and improving and sustaining the local antiinflammatory effect of aceclofenac
  • This formulation seems to represent an attractive strategy for sustained delivery of aceclofenac
  • The results of the present study demonstrated that Hydroxyl propyl methylcellulose niosomal gel formulation containing span 20: cholesterol possesses great potential for prolonging release, enhancing skin permeation and improving and sustaining the local antiinflammatory effect of aceclofenac

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