Personalized Medicine Toward Multiple Sclerosis;Current Challenges and Future Prospects

This review aims to provide an overview of some new developments in the pharmacogenomics of Multiple sclerosis as well as an outlook on the new approaches in the development of the personalized medicine

Mohammad Reza Javan; Ahmadali Jalali Nezhad; Amin Safa; Mohammad Hassan Mohammadi; khosro Jamebozorgi

2017

Scholarcy highlights

  • Pharmacogenomics is defined as the survey and application of the individual patients’ specific genetic background to predict the quality and quantity of response to drug treatment
  • This review aims to provide an overview of some new developments in the pharmacogenomics of Multiple sclerosis as well as an outlook on the new approaches in the development of the personalized medicine
  • Glatiramer Acetate Glatiramer acetate is the first-line disease-modifying therapies that is prescribed for relapsing types of MS, and as compared with IFN-β, less pharmacogenomic trials have evaluated the GA response around the personalized medicine, with promising results underlying the effect of genetic variations for clinical testing
  • Incongruous and various types of responses have been observed in the MS patients receiving the DMTs
  • These patients need to be implemented with predictive examinations under the personalized medicine concepts to orientate them toward more efficient treatments
  • It is totally believed that pharmacogenomics and pharmacoepigenetics have the potential to be applied in the MS therapy and improve the therapeutic profile of the MS patients considering the cost of the treatment, efficacy of the drug agent, and duration of the patients’ improvement
  • It is totally believed that pharmacogenomics and pharmacoepigenetics have the potential to be applied in the Multiple sclerosis therapy and improve the therapeutic profile of the MS patients considering the cost of the treatment, efficacy of the drug agent, and duration of the patients’ improvement

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