Pharmaceutical composition for treating macular degeneration (WO2012079419)

Age-related macular degeneration is a leading cause of blindness among the elderly in the industrialized world, affecting more than 30 million individuals globally

Shusheng Wang; Khrishen Cunnusamy

2012

Scholarcy highlights

  • Age-related macular degeneration is a leading cause of blindness among the elderly in the industrialized world, affecting more than 30 million individuals globally
  • In USA alone, about 1.8 million individuals are afflicted by this disease and the number is projected to increase to an epidemic level of approximately 3 million by 2020
  • Age-related Macular Degeneration is characterized by yellow drusen deposits and hypo- or hyper-pigmentation in the choroid/retinal pigment epithelium layers in the macula
  • Using a laser-induced Choroidal neovascularization rat model, Jin and colleagues compared the effect of the Traditional Chinese Medicine, Avastin and saline-treated control on fluorescein leakage and CNV area
  • The authors found that the TCM group was comparable to the Avastin group, and had significantly less vascular leakage compared to the saline controls
  • Histopathological and electron microscopy analyses showed a similar decrease in retinal and choroidal capillary damage, decreased CNV and limited proliferation and migration of RPE cells, fibroblast and collagen fibers in both the TCM and Avastin-treated groups compared to the saline control group
  • If Traditional Chinese Medicine treatment does inhibit dry Age-related Macular Degeneration, this will support the concept that TCM-based medicine can treat both the symptoms and the causes of AMD; making it an appealing therapeutic agent to AMD individuals

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