Paramagnetic micro-particles as a tool for rapid quantification of apixaban, dabigatran, edoxaban and rivaroxaban in human plasma by UHPLC-MS/MS

Martin H.J. Wiesen

2017

We evaluated two independent extraction methods and developed a multi-analyte ultra-high performance liquid chromatography tandem mass method for the quantification of apixaban, dabigatran, edoxaban and rivaroxaban in human plasma.Methods:Routine extraction based on protein precipitation with acetonitrile and subsequent centrifugation was compared to sample clean-up using commercial paramagnetic micro-particles and subsequent magnetic depletion

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