Genetic variants and risk of thyroid cancer among Iranian patients

This review presents for the first time a summary of important genetic markers in Iranian patients with thyroid cancer

Mohammad Jamshidi; Gholamreza Farnoosh; Somayeh Mohammadi Pour; Fatemeh Rafiee; Ali Saeedi Boroujeni; Mohammad-Reza Mahmoudian-Sani

2021

Scholarcy highlights

  • The definition of an exclusive panel of genetic markers is of high importance to initially detect among this review population
  • We gave a summary of each main genetic marker among Iranian patients with thyroid cancer for the first time which were classified based on their cellular function
  • A significant relationship was found between SNP in codons 194, 280, and 399, Allele 3434Thr, GC or CC genotype 31, G/C, 399G>A, Tru9I, G‐D haplotype, TT genotype, −656 G/T, TAGTT haplotype, G allele in +49 A>G, +7146 G/A, +7785 C/T, rs1143770, rs4938723 genes, and thyroid cancers
  • Conduct further studies on the types of DNA repair gene polymorphisms with a larger number in the thyroid cancer using modern methods such as SNP array so that these genes could be used as a biomarker in prediction, diagnosis, and treatment of thyroid cancer
  • This review presents for the first time a summary of important genetic markers in Iranian patients with thyroid cancer

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