Induction of Cytosolic Triiodo-L-Thyronine (T3) Binding Protein (CTBP) by T3 in Primary Cultured Rat Hepatocytes.

We examined whether the CTBP activity could be induced by T3 or not in cultured hepatocytes prepared from thyroidectomized rats

YUTAKA NISHII; KIYOSHI HASHIZUME; KAZUO ICHIKAWA; TEIJI TAKEDA; MUTSUHIRO KOBAYASHI; TAKESHI NAGASAWA; MIYUKI KATAI; HIROAKI KOBAYASHI; AKIHIRO SAKURAI

2008

Scholarcy highlights

  • Cytosolic 3, 5, 3'-triiodo-L-thyronine-binding protein plays an important role in the regulation of intracellular T3 translocation from cytoplasm to the nuclear T3 receptor
  • We examined whether the CTBP and malic enzyme could be induced by T3 or not in cultured hepatocytes prepared from thyroidectomized rat
  • Effectof T3 on the levelsof CTBP and activityof malic enzyme in cultured hepatocytesprepared from thyroidectomizedrats
  • We demonstrated that thyroid hormone increased the level of NADPH-dependent cytosolic T3 binding in rat liver and kidney in vivo
  • We could not evaluate whether the mechanism of the action of thyroid hormone is direct or indirect
  • We demonstrated that thyroid hormone increased the maximal binding capacity for
  • We confirmed that thyroid hormone increased the level of activity of malic enzyme in the isolated hepatocytes prepared from thyroidectomized rats

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