Histamine, histamine receptors, and anti-histamines in the context of allergic responses

We describe the roles of these histamine receptors and antihistamines in the human system, clinical applications, side effects, and novel concepts for the usage of antihistamines with different specificity based on guidelines and recommendations

Amarilla Mandola; Asako Nozawa; Thomas Eiwegger


Scholarcy highlights

  • Histamine is a bioactive amine that acts as a signalling molecule and neurotransmitter
  • Atopic diseases are a great burden to patients, from the young to the elderly
  • The various isoforms of H3 receptors which are linked to different signaling pathways leading to selective regulation of diverse cerebral functions, and the H4 receptors’ direct activating function of effector cells of the haematopoietic system and to the expression on regulatory T cells
  • These are all explored in order to better understand their mechanism, effect, and role in the development of atopic diseases and developing new therapeutic agents for the management of atopic dermatitis, allergies, and asthma
  • The significance of P-glycoprotein expression expression is in its limiting effects on the central nervous system, by actively pumping out the substrate, in this case, second generation non sedative antihistamines that may pass through the blood brain barrier
  • We provide a review of the histamine receptor, their function and role in disease, the most important antihistamines currently available, as well as their pharmacological effects and side effect potential
  • Careful assessment of potential side effects is important before starting long term or high dose treatment for each antihistamine medication including concomittant illnesses and therapies to achieve the best individualized therapy

Need more features? Save interactive summary cards to your Scholarcy Library.