Peroxiredoxins and the Regulation of Cell Death

Cells employ a complex array of antioxidants to protect themselves from oxidative stress

2016

Scholarcy highlights

  • Cells employ a complex array of antioxidants to protect themselves from oxidative stress
  • In this scenario reactive oxygen species act as second messengers, with a carefully regulated increase in generation mediating the post-translational modification of specific regulatory proteins
  • A significant amount of published data supports a model in which steady state levels of hydrogen peroxide increase during the initiation of apoptosis, and this acts as a signaling molecule to promote cell death
  • It is difficult to separate causative processes from those that occur as a consequence of cell death
  • To determine the importance of intracellular redox changes in apoptosis, it is crucial that the precise mechanisms are unraveled, thereby enabling the development of selective inhibitors
  • The Prxs appear to play a significant role in redox signaling, and the disruption of their catalytic activity and protein interactions may prove to be a valuable tool
  • Studies on the role of Prxs in necroptosis are warranted, as is their ability to act as markers of redox disruption prior to the induction of cell death

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