A Dual Role for Apolipoprotein E in Neuroinflammation: Anti- and Pro-Inflammatory Activity

To further characterize the effect of Apolipoprotein E on inflammation, we examined the ability of exogenously added human Apolipoprotein E3 and apoE4 to modulate neuroinflammatory responses of cultured rat glia

Ling Guo; Mary Jo LaDu; Linda J. Van Eldik

2004

Scholarcy highlights

  • Activated glia associated with amyloid plaques might contribute to neuronal dysfunction in Alzheimer’s disease through generation of neuroinflammatory molecules
  • To further characterize the effect of Apolipoprotein E on inflammation, we examined the ability of exogenously added human Apolipoprotein E3 and apoE4 to modulate neuroinflammatory responses of cultured rat glia
  • Exogenous apoE in the absence of Aβ stimulated production of the pro-inflammatory cytokine interleukin-1β in an isoform-dependent manner, with apoE4 inducing a significantly greater response than apoE3. These data support the idea that Aβ stimulation of glial apoE limits neuroinflammation but that overproduction of apoE by activated glia might exacerbate inflammation
  • The observation that apoE4 has more robust pro-inflammatory activity than apoE3 provides a mechanistic link between the APOE4 allele and AD, and suggests potential apoE-based therapeutic strategies
  • & Van Eldik, L.J. A dual role for apolipoprotein E in neuroinflammation

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