Dynamic Contrast-Enhanced MRI of Malignant Pleural Mesothelioma

Tumor regions were characterized by the pharmacokinetic parameters amplitude, redistribution rate constant, and elimination rate constant

Frederik L. Giesel

2006

Scholarcy highlights

  • Dynamic contrast-enhanced MRI followed by pharmacokinetic analysis has been successfully used in a variety of solid tumors
  • Tumor regions were characterized by the pharmacokinetic parameters amplitude, redistribution rate constant, and elimination rate constant
  • Patients were classified as clinical responders or nonresponders according to clinical outcome, and these groups were compared with the pharmacokinetic parameters derived from Dynamic contrast-enhanced MRI
  • Normal and tumor tissue could be distinguished by the pharmacokinetic parameters Amp and kel
  • DCE-MRI can be used in patients with malignant pleural mesothelioma to assess tumor microvascular properties and to demonstrate tumor heterogeneity for therapy monitoring
  • High pretherapeutic values of kep within the tumor correlated with a poor overall response to therapy

Need more features? Save interactive summary cards to your Scholarcy Library.