Synthesis of Luminescent Graphene Quantum Dots with High Quantum Yield and Their Toxicity Study

We develop an ameliorative photoFenton reaction followed by a simple hydrothermal process to prepare luminescent Graphene quantum dots with higher PL quantum yield

Dan Jiang; Yunping Chen; Na Li; Wen Li; Zhenguo Wang; Jingli Zhu; Hong Zhang; Bin Liu; Shan Xu


Scholarcy highlights

  • Graphene quantum dots, a kind of promising carbon-based luminescent materials, have drawn researchers attention to biomedicine fields owing to their excellent optical-electronic characteristics and superior biocompatibility
  • When exposed to high concentration of 200 μg/mL, the Lactate dehydrogenase release level increased almost 50% compared with the control group, which might be speculated to be the reason that GQDs could contact with cell membrane and cause the corresponding physical membrane damage
  • GQDs were successfully fabricated by ameliorative photo-Fenton reaction and hydrothermal process
  • As-prepared GQDs emitted intense green luminescence under ultraviolet excitation and the fluorescence quantum yield was as high as 24.6%
  • The cytotoxicity of GQDs was evaluated by counting kit-8, LDH, Reactive oxygen species and Annexin-V apoptosis assays
  • The in vivo test further demonstrated that low-dose of GQDs had little influences on zebrafish embryos and larvae
  • As-prepared Graphene quantum dots with strong PL and good biocompatibility had great potential in biological and medical applications

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