Combination of MiR-103a-3p and Mesothelin Improves the Biomarker Performance of Malignant Mesothelioma Diagnosis

Conclusions/Significance: The results of this study show that the combination of mesothelin and miR-103a-3p improves the diagnostic performance of individual blood-based biomarker to detect malignant mesothelioma

Daniel G. Weber

2014

Scholarcy highlights

  • Malignant mesothelioma is an aggressive cancer of the serous membranes with increasing incidence worldwide
  • Methods/Principal Findings: Mesothelin concentration in plasma and miR-103a3p levels in the cellular blood fraction were analyzed in 43 male mesothelioma patients and 52 male controls formerly exposed to asbestos
  • Conclusions/Significance: The results of this study show that the combination of mesothelin and miR-103a-3p improves the diagnostic performance of individual blood-based biomarker to detect malignant mesothelioma
  • Distribution of mesothelin concentrations and normalized miR-103a-3p levels in the two study groups are shown in Figure 1
  • Mesothelin showed a median concentration of 2.01 nmol/l for epithelioid, 2.01 nmol/l for biphasic, and 0.75 nmol/l for sarcomatoid mesothelioma
  • Applying the calculated cut-off based on receiver operating characteristic analysis with maximum Youden’s index of the combination of mesothelin and miR-103a-3p, sarcomatoid mesothelioma showed an increased odds ratios of 72 to be tested false-negative, whereas all other group characteristics showed no significant altered OR to be tested false-negative or false-positive
  • We showed that the combination of mesothelin and miR-103a3p improved the diagnostic performance of a blood-based screening test, resulting in higher sensitivity and specificity to detect malignant mesothelioma

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