Inter Individual Variations of the Fish Skin Microbiota: Host Genetics Basis of Mutualism?

Our results provide evidence that host genotype may regulate the abundance of specific genera among their surface microbiota

Sébastien Boutin; Christopher Sauvage; Louis Bernatchez; Céline Audet; Nicolas Derome

2014

Scholarcy highlights

  • The study of the beneficial effects of bacteria and their influence on host health is a growing field
  • Interindividual variation in abundance of each bacterial strain detected in host microbiota was afterwards projected on the results of the genetic linkage map in order to identify quantitative trait loci of specific skin bacterial operational taxonomic units
  • 87,940 high-quality, classifiable sequences were obtained with an average number of 10226540 per sample, which were subsequently classified in OTUs
  • We focused on the structural variation of the skin microbiota of an F2 intercross originally generated from two genetically contrasted strains of brook charr
  • A change in skin microbiota taxonomic structure favors opportunist bacteria and especially opportunistic pathogens like F. psychrophilum, Acinetobacter haemolyticus, Acinetobacter johnsonii and Acinetobacter junii, which have a higher abundance in group 2 compared with group 1 Such a disturbance in the microbiome homeostasis is called dysbiosis, and its occurrence enlightens the importance of the function of M. rhodesianum in controlling the balance between both other commensal bacteria and opportunistic pathogens
  • Arrows represent genus, which are significantly correlated with the axis
  • Skin microbiota taxonomic structure varies significantly across the F2 progeny. This result added to the fact that i the genetics of the host is the only variable in the experiment, and ii the finding of three Quantitative Trait Loci associated to the abundance of bacterial genera with high PVE, suggest that host
  • Linkage analysis on genus abundance data strongly evidenced the influence of host genetics on the modulation and/or recruitment for those genera

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