A Prospective Study of Plasma Vitamin D Metabolites, Vitamin D Receptor Polymorphisms, and Prostate Cancer

During 18 y of follow-up of 14,916 men initially free of diagnosed cancer, we identified 1,066 men with incident prostate cancer and 1,618 cancer-free, age- and smoking-matched control participants in the Physicians’ Health Study

Haojie Li


Scholarcy highlights

  • Recent National Health and Nutrition Examination Survey data demonstrated that vitamin D insufficiency is a common public health problem nationwide, especially for elderly and minority populations
  • We examined the associations of prediagnostic plasma levels of 25(OH)D and 1,25(OH)2D, individually and jointly, with total and aggressive disease, and explored whether relations between vitamin D metabolites and prostate cancer were modified by the functional vitamin D receptor FokI polymorphism, using conditional logistic regression
  • Our data suggest that a large proportion of the US men had suboptimal vitamin D status, and both 25(OH)D and 1,25(OH)2D may play an important role in preventing prostate cancer progression
  • The only study on the joint associations of circulating vitamin D levels and the VDR BsmI polymorphism with prostate cancer came from our group, showing that the BsmI BB genotype was associated with lower risk among men with low 25(OH)D status
  • 75% of the blood samples were collected during summer/fall, among which levels of 25(OH)D and 1,25(OH)2D were significantly and positively correlated; they were unrelated among samples collected during winter/spring
  • We observed a significant interaction between circulating 25(OH)D levels and the VDR FokI genotype. Compared with those with plasma 25(OH)D levels above the median and with the FokI FF or Ff genotype, men who had low 25(OH)D levels and the less functional FokI ff genotype had increased risks of total and aggressive prostate cancer
  • The overall vitamin D status of the participants in this cohort was similar to several other studies as well as to US men in NHANES
  • Men with the less functional FokI ff genotype are more susceptible to this cancer in the presence of low 25(OH)D status

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