Bupropion versus Selective Serotonin-Reuptake Inhibitors for Treatment of Depression

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Carmine E Nieuwstraten; Lisa R Dolovich

2003

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  • DATA SYNTHESIS: Six full-length studies were included of 257 citations identified
  • The absolute weighted mean differences were 0.10 for the CGI for Severity of Illness and 0.37 for the Hamilton Rating Scale for Anxiety measurements
  • Relative risks of bupropion compared with SSRIs were 0.6, 0.31, and 0.27 for nausea, diarrhea, and somnolence, respectively
  • Orgasmic dysfunction, and sexual desire disorder occurred less with bupropion than with SSRIs, with relative risks of 0.46, 0.22, and 0.65, respectively
  • Bupropion and SSRIs have similar effectiveness; bupropion was associated with less nausea, diarrhea, somnolence, and sexual dysfunction

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