Effects of Ammonium Perchlorate on Thyroid Function in Developing Fathead Minnows,Pimephales promelas

In investigating the effects of perchlorate, we focused on the first 28 days of development from < 24 hr postfertilization through the transition to juvenile fish

Helen M. Crane; Daniel B. Pickford; Thomas H. Hutchinson; J. Anne Brown

2005

Scholarcy highlights

  • Perchlorate has several chemical properties that make environmental contamination difficult to resolve and decontamination difficult to achieve
  • Wet weight and standard length were significantly lower in fish exposed to 10 mg/L and 100 mg/L ammonium perchlorate compared with fish exposed to 1 mg/L perchlorate and controls
  • In our studies, despite the observed effects of ammonium perchlorate on growth and development of fathead minnows achieved over the 28-day experiment, there was no evidence of a significant depression in whole-body thyroid hormones after this period of exposure
  • The results reported here indicate that environmentally relevant levels of ammonium perchlorate are likely to affect the thyroid axis of teleost fish
  • Growth and development of the early life stages of fathead minnows were significantly retarded after a 28-day exposure to 10 or 100 mg/L perchlorate, and we suggest that these changes are the result of hypothyroidism during the early stages of exposure
  • There was no significant difference between the whole-body T3 content of control fish and that of any group of fish exposed to ammonium perchlorate
  • Further studies are needed to investigate whether there is up-regulation of T4 production or increased release at this stage in exposure. It remains to be determined how fathead minnows exposed to perchlorate would survive and function in the longer term and, given the impeded growth and development, whether these fish would reach sexual maturity

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