Functional toxicology: a new approach to detect biologically active xenobiotics.

Many chemicals with different structures were shown to exhibit weak estrogenlike functions

J A McLachlan

2011

Scholarcy highlights

  • Many chemicals with different structures were shown to exhibit weak estrogenlike functions
  • 1985 that a body of data was presented which addressed the effect of environmental estrogens on puberty in young children
  • A meeting held in 1992, organized by the World Wildlife Fund, explored the premise that these compounds may have a deleterious effect on sexual development in a variety of wildlife species
  • In the case of chemicals which interact with the estrogen receptor, it is clear that their activity is defined more by their function than by their structure
  • Screening for functionality could be made fairly broad by having the panels indude the estrogen receptor, progesterone receptor, androgen receptor, glucocorticoid receptor, retinoid receptor, thyroid hormone receptor, peroxisome proliferator receptor, dioxin receptor, excitatory amino acid receptors, and so on
  • One could develop further a plan to target either additional tests or public health approaches for these chemicals based on their functional toxicology

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