Influence of Polysorbate 60 on Formulation Properties and Bioavailability of Morin-Loaded Nanoemulsions with and without Low-Saponification-Degree Polyvinyl Alcohol

Morin Its wide spectrum of biological activities, including anti-inflammatory, anti-cancer, antioxidant, antiangiogenic, anti-hypertensive, and anti-clastogenic activities, have been reported.2–8) We previously demonstrated that a treatment with morin induced basal nitric oxide production and rapid improvements in endothelial function in diabetic mice.9) Morin has been suggested to improve the development of endothelial dysfunction by diabetes

Yuri Ikeuchi-Takahashi

2018

Scholarcy highlights

  • Influence of Polysorbate 60 on Formulation Properties and Bioavailability of Morin-Loaded Nanoemulsions with and without LowSaponification-Degree Polyvinyl Alcohol
  • medium chain triglycerides-LL810 nanoemulsion containing LL-810 was prepared with a reduced amount of Tween 60
  • Non-ionic surfactants are inhibitors of intestinal P-gp.16,17) Regarding the well-known P-gp substrate digoxin, Tween 80 was reported to improve its intestinal absorption in vitro and in vivo.18) Zhang et al concluded that this effect was most likely caused by the inhibition of P-gp in the gastrointestinal tract and that a similar enhancement may be achieved for other P-gp substrates.19) in nanoemulsions containing drugs with low aqueous solubility that serve as a substrate for P-gp, their pharmacokinetics after their oral administration may be modified by improving drug solubility and inhibiting P-gp using surfactants
  • In MCT nanoemulsion, needle-like crystals estimated to be due to morin were included
  • In order to improve the oral bioavailability of morin, morinload nanoemulsions containing a large or small amount of Tween 60 were prepared, and the influence of the amount of Tween 60 added on formulation properties and bioavailability was investigated
  • Dispersed droplets in medium chain triglycerides-LL810 nanoemulsion containing LL-810 rapidly permeated through the mucus layer and intestinal membrane, and Tween 60 incorporated into dispersed droplets interacted with P-gp-mediated efflux, increasing the bioavailability of morin

Need more features? Save interactive summary cards to your Scholarcy Library.