Formulation and Evaluation of Solid Lipid Nanoparticles of a Water Soluble Drug: Zidovudine

The present investigation was undertaken to develop solid lipid nanoparticles of a hydrophilic drug Zidovudine and improve the entrapment efficiency of the drug in SLN

Sanjay Singh

2010

Scholarcy highlights

  • The present investigation was undertaken to develop solid lipid nanoparticles of a hydrophilic drug Zidovudine and improve the entrapment efficiency of the drug in SLN
  • SLN have been shown to have superior advantages over polymeric nanoparticles, fat emulsion and liposomes.14) SLN can be produced on large scale and are biocompatible to the body as compared to polymers, the monomeric unit of which are cytotoxic to the body.15,16) SLN exhibit sustained release effect due to the immobility of drug within lipid as compared to the emulsion formulations17) and exhibit better physical and chemical stability of drug compared to liposome.18) This delivery system has been extensively used as carriers for proteins, protein drugs, vaccines and lipophilic water insoluble drugs.19)
  • It is evident that polyvinyl alcohol while imparting emulsion stability will not increase the solubility of drug in external phase during formulation which is one of the major reasons for reduced loading efficiency in the fabrication of SLN
  • The major outcome of this work was the successful entrapment of a hydrophilic drug within a lipid core
  • A comparative study of the fabricated SLN using fatty acid and TG and their combinations clearly shows the superior capacity of the fatty acids over TGs to encapsulate the model hydrophilic drug
  • It was found that PVA decreased the solubility of AZT which may be one of the reasons for attaining the highest entrapment efficiency reported so far for this drug

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