A simple and efficient method for apolipoprotein E genotype determination

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J. Chapman; J. Estupinan; A. Asherou; L. G. Goldfarb


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  • There is currently much interest in the role of apolipoprotein E genotype in late-onset Alzheimer's disease, and examination of this question involves the genotyping of large groups of cases. 1,2 Many of the studies have used the method of apoE genotyping described by Hixson and Vernier 3, which has the advantage of using a single restriction enzyme to identify two polymorphic sites
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