ApoE- 4 is associated with reduced memory in long-standing intractable temporal lobe epilepsy

Presurgical and postsurgical memory performance was examined in 87 adult patients with temporal lobe epilepsy to determine whether the expression of ApoE-ε4 may be associated with memory performance in this population and to examine how this relationship may be affected by duration of epilepsy

R. M. Busch; T. T. Lineweaver; R. I. Naugle; K. H. Kim; Y. Gong; C. Q. Tilelli; R. A. Prayson; W. Bingaman; I. M. Najm; R. Diaz-Arrastia

2007

Scholarcy highlights

  • Presurgical and postsurgical memory performance was examined in 87 adult patients with temporal lobe epilepsy to determine whether the expression of ApoE-ε4 may be associated with memory performance in this population and to examine how this relationship may be affected by duration of epilepsy
  • There was a significant interaction between ApoE-ε4 status and duration of epilepsy such that ε4 carriers with a long duration of epilepsy demonstrated the poorest memory performance on both verbal and nonverbal measures
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