A Comprehensive Analysis ofMNG1,TCO1,fPTC,PTEN,TSHR, and TRKA in Familial Nonmedullary Thyroid Cancer: Confirmation of Linkage to TCO1

None of the families we examined in this study showed significant linkage to the putative familial NONMEDULLARY thyroid cancer thyroid cancer genes MNG1 or fPTC

S. Bevan; T. Pal; C. R. Greenberg; H. Green; J. Wixey; G. Bignell; S. A. Narod; W. D. Foulkes; M. R. Stratton; R. S. Houlston

2014

Scholarcy highlights

  • MOST NONMEDULLARY thyroid cancer is sporadic
  • All 21 potentially informative families were used in the linkage study of PTEN, TSHR, TRKA, TCO1, MNG1, and fPTC loci
  • The putative gene fPTC was mapped in a family with 5 cases of papillary thyroid cancer, 3 cases of thyroid nodules, and 2 cases of papillary renal neoplasia to chromosome 1q21
  • None of the families we examined in this study showed significant linkage to the putative familial NMTC thyroid cancer genes MNG1 or fPTC
  • Two other reports have found that the majority of FNMTC kindreds are not linked to MNG1
  • We evaluated TSHR as a candidate gene for FNMTC, as it is implicated in benign thyroid disease, and activating mutations may affect thyroid cellular differentiation
  • Subcategorization of NONMEDULLARY thyroid cancer families on the basis of phenotype provides a powerful strategy for enhancing the power of future linkage studies, especially if the involvement of known genes can be excluded

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