Increased Hypothalamic Content of Preproneuropeptide Y Messenger Ribonucleic Acid in Genetically Obese Zucker Rats and Its Regulation by Food Deprivation*

In this study we investigated the possibility that preproNPY messenger RNA content may be altered in obese Zucker rats compared to that of their lean littermates

GERARD SANACORA

2009

Scholarcy highlights

  • Presented in part at the 19th Annual Meeting of the Society for Neuroscience, Phoenix, AZ, 1989
  • In this study we investigated the possibility that preproNPY messenger RNA content may be altered in obese Zucker rats compared to that of their lean littermates
  • The results revealed a 2- to 3-fold increase in preproNPY messenger RNA levels in the hypothalamus of obese animals compared to lean
  • An additional RNase protection study was pursued to investigate the effects of 72 h food deprivation on hypothalamic preproNPY mRNA levels in lean and obese animals
  • Lean animals displayed an approximate 2-fold increase in preproNPY mRNA content, whereas obese animals showed no significant increase after food deprivation
  • These data are consistent with the hypothesis that Neuropeptide Y projections within the hypothalamus are involved in regulating feeding behavior and weight gain, and that disturbed regulation of hypothalamic NPY expression may play a role in the etiology of obesity in the genetically obese Zucker rat.
  • Agouti-Related Peptide, Neuropeptide Y, and Somatostatin-Producing Neurons Are Targets for Ghrelin Actions in the Rat Hypothalamus

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