Thyroglobulin Degradation by Thyroidal Proteases: Action of Thiol Endopeptidases in Vitro*

The results show that thiol endopeptidases are present in the thyroid gland and are collectively as important as cathepsin D in the hydrolysis of thyroglobulin in vitro

ANN D. DUNN; JOHN T. DUNN

2009

Scholarcy highlights

  • We have obtained evidence of thiol endopeptidases in the thyroid which are active in thyroglobulin degradation in vitro
  • The action of the thiol endopeptidases onthyroglobulin was analyzed by polyacrylamide gel electrophoresis in sodium dodecyl sulfate or in sodium dodecyl sulfate and urea
  • Each of the thiol endopeptidases had a synergistic effect when incubated with cathepsin D andthyroglobulin
  • The results show that thiol endopeptidases are present in the thyroid gland and are collectively as important as cathepsin D in the hydrolysis of thyroglobulin in vitro
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